Luteolin and Testosterone

Unfortunately, in the world of natural testosterone boosters, some ingredients have a tendency to come and go. An exciting new component which we’re told is absolutely key to unlocking our body’s peak performance one day, might be gone the next, along with the cash we spent on it in good faith.

That’s why consistency is so often a mark of quality and why we keep an eye out for those ingredients which regularly find their way into the best testosterone supplements available. Luteolin would definitely be one such fixture. Here we’ll look at precisely how luteolin helps to stimulate our testosterone and why it remains such a popular inclusion for so many quality brands.

Luteolin is a Flavone, a type of flavonoid, which is found mainly in nature within the leaves and bark of the Terminalia Chebula tree. Before you decide to head off for your nearest forest with a chainsaw and a bottle of barbeque sauce though, it’s worth mentioning luteolin is also present in slightly more palatable vegetable options, such as celery, broccoli, carrots and green pepper, as well as herbs like parsley, thyme, peppermint and oregano.

General benefits of luteolin include it’s qualities as a potent antioxidant, helping to regulate metabolism, boost the immune system and manage type 2 diabetes.

Does It Boost Testosterone?

Luteolin’s primary function when it comes to raising testosterone is as an incredibly effective aromatase inhibitor, which means it regulates the amount of estrogen active in our system.

Despite its title of the female hormone, guys too have varying amounts of estrogen in their system at any one time. You’re probably familiar with the term hormonal balance; well testosterone and estrogen are on opposite ends of that balance, meaning that when one is plentiful the other will be in short supply.

By blocking the aromatase enzyme, luteolin stops androgens being converted to estrogen leading to lower amounts of it in in the body, which clears the way for much higher levels of testosterone. We know just how effective luteolin is thanks to a study by The Chinese Academy of Sciences which compared it against over 1,400 different natural compounds and found it be superior to all of them in its ability to reduce estrogen.


As previously touched on earlier, luteolin has been shown to be a potent antioxidant. This brings with it a number of general health benefits, but also has a specific advantage with regards to our testosterone.

Often, one of the reasons for low testosterone is oxidative damage to the Leydig cells in the testes, leading to poor function, which can hinder testosterone production. Research conducted by the Department of Pharmacy at the National University of Singapore recently concluded that;

“luteolin was evaluated to possess direct and indirect antioxidant activities by scavenging free radicals and inducing the upregulation of ARE-dependent phase II enzymes.”

This makes luteolin an ideal candidate to reduce the sort of internal wear and tear that might negatively impact your ability to create testosterone.


So while luteolin may not aid testosterone quite as directly as the likes of D-Aspartic Acid, zinc, vitamin D3 or magnesium for example, it still has a vital role to play as sort of a personal security guard to those stars; clearing a path, making sure nothing gets in their way or stops them doing their job.

Luteolin isn’t the only ingredient with aromatase inhibiting and antioxidant qualities, but it is one of the best, particularly on that first count. Coming out on top when clinically compared to so many natural estrogen reducing alternatives explains why it is the go-to choice of a top age related testosterone booster like Prime Male.

There are always going to be fad ingredients in this industry but based on the wealth of evidence out there, luteolin was never going to be one of them.

Study 1: Chengdu Institute of Biology Study (2012)

Title: Inhibitory effect of luteolin on estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19)..
Researchers: Lu DF, Yang LJ, Wang F, Zhang GL.
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Study 2: National University of Singapore Study (2013)

Title: Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia Hance, provide neuroprotective effects against ischemia-induced cellular injury..
Researchers: Zhang YC, Gan FF, Shelar SB, Ng KY, Chew EH.
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Comment List

  • Tobal86 17th September 2017

    As you said, some ingredients come and go.

    Showing that luteolin is a potent aromatase inhibitor is not enough to affirm it has a antagonist estrogen effect.

    Unfortunatly, the contrary has been shown :
    “Luteolin displays potent progesterone antagonist and estrogen agonist activities and weaker glucocorticoid antagonist activity.”

    • Thorium 17th May 2018

      Read the whole paper not just the title. The WB data is questionable plus the crystalography modeling is based on an entirely different molecule. Also only one cell type is really used here. With no Affymetrix or proteomics data I have issues with the data and conclusions. Read the paper, don’t just blindly post Titles.